论文部分内容阅读
目的：探讨血清αＬ岩藻糖苷酶（ＡＦｕ）、甲胎蛋白（ＡＦＰ）和癌胚抗原（ＣＥＡ）在不同慢性肝病中检测的临床意义。方法：应用微量分光光度法和酶联免疫法对２１０例正常人及慢性肝病患者检测血清ＡＦｕ和ＡＦＰ、ＣＥＡ。结果：各组ＡＦｕ均高于正常对照组（Ｐ＜００１），其中原发性肝癌组（ＰＨＣ）最高，中、重型慢性肝病高于轻型慢性肝病，活动性肝硬化高于静止性肝硬化（Ｐ＜００５或＜００１）。ＰＨＣ组ＡＦＰ＜２５μｇ／Ｌ与ＡＦＰ＞２５μｇ／Ｌ二者间ＡＦｕ阳性率无显著差异，而慢性肝病和肝硬化组均有显著差异。ＰＨＣ组与消化道肿瘤转移肝癌组的ＡＦｕ、ＡＦＰ、ＣＥＡ阳性率明显不同。结论：血清ＡＦｕ在ＰＨＣ中敏感性较高，在其它慢性肝病中也有升高，但似与肝损害程度有关，并不意味着恶性变。联合检测ＡＦｕ与ＡＦＰ可提高ＰＨＣ的诊断率。ＡＦｕ与ＣＥＡ在鉴别ＰＨＣ与消化道肿瘤转移肝癌方面有一定诊断价值。
Objective: To investigate the clinical significance of detecting α-L-fucosidase (AFu), AFP and CEA in different chronic liver diseases. Methods: Serum AFu, AFP and CEA were detected in 210 normal subjects and patients with chronic liver diseases by using the method of micro-spectrophotometry and enzyme-linked immunosorbent assay. Results: The AFu in each group was higher than that in the normal control group (P <001). Among them, PHC was the highest, moderate and severe chronic liver disease was higher than that of light chronic liver disease, and active cirrhosis was higher than that of resting liver Hardened (P <005 or <001). There was no significant difference in AFu positive rate between AFP <25μg / L and AFP> 25μg / L in PHC group, but there was significant difference in chronic liver disease and cirrhosis group. The positive rates of AFu, AFP and CEA in PHC group and gastrointestinal tumor metastatic HCC group were significantly different. CONCLUSIONS: Serum AFu is highly sensitive in PHC and elevated in other chronic liver diseases, but it seems to be related to the degree of liver damage and does not mean malignant transformation. Joint detection of AFu and AFP can improve the diagnostic rate of PHC. AFu and CEA in the identification of PHC and gastrointestinal cancer metastasis of liver cancer has a certain diagnostic value.