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目的:检测2型糖尿病伴重度牙周病患者血浆纤维蛋白原(plasma fibrinogen,Fbg)水平变化,探讨2型糖尿病患者Fbg与重度牙周病的关系。方法:选择2型糖尿病伴重度牙周病患者24例、糖尿病无牙周病患者20例、健康对照组16例,测定Fbg的同时,测定体质指数、血脂、糖化血红蛋白(HbA1c)等临床、生化指标。结果:2型糖尿病伴牙周病组血浆Fbg水平显著高于2型糖尿病无牙周病组及健康对照组,糖尿病无牙周病组显著高于对照组(P<0.05);血浆Fbg与HbA1c、胰岛素抵抗指数(HOMA-IR)呈正相关。结论:牙周病可能导致2型糖尿病患者Fbg水平升高,这种炎性介质可能进一步加重糖、脂代谢异常,加重胰岛素抵抗。
Objective: To investigate the changes of plasma fibrinogen (Fbg) level in type 2 diabetic patients with severe periodontal disease and to explore the relationship between Fbg and severe periodontal disease in type 2 diabetic patients. Methods: Twenty-four patients with type 2 diabetes mellitus with severe periodontal disease, 20 patients without diabetes mellitus with periodontal disease and 16 healthy controls were enrolled in this study. Body mass index, blood lipid, HbA1c and other clinical and biochemical parameters index. Results: The plasma levels of Fbg in type 2 diabetic patients with periodontal disease were significantly higher than those in type 2 diabetic patients without periodontal disease and healthy controls, and those with no periodontal disease in diabetic patients were significantly higher than those in control group (P <0.05). The levels of plasma Fbg and HbA1c , Insulin resistance index (HOMA-IR) was positively correlated. Conclusion: Periodontal disease may lead to increased Fbg levels in type 2 diabetic patients. This inflammatory mediator may further aggravate the abnormal glucose and lipid metabolism and aggravate insulin resistance.