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目的:研究人视黄醇结合蛋白4(RBP4)水平与冠心病及1年预后关系。方法:选择因疑诊冠心病而行冠状动脉造影的140例非糖尿病患者,其中确诊冠心病患者94例,非冠心病患者46例(作为对照)。采用ELISA试剂盒(德国IBL公司)检测140例患者血浆RBP4水平。冠心病患者出院后完成1年随访,记录主要不良心脏事件(MACEs),即再发心绞痛、再发心肌梗死、心力衰竭恶化和心源性死亡。多变量回归分析RBP4与1年随访MACEs关系。结果:与对照组比,冠心病组高血压、吸烟比例、年龄和RBP4水平[(51.69±34.96)μg.ml-1比(37.84±15.94)μg.ml-1]均显著升高或增长(均P<0.05)。冠心病组发生MACEs共8例,事件组平均RBP4水平显著高于无事件组[(76.12±42.89)μg.ml-1比(46.24±17.66)μg.ml-1,P<0.01],事件组ρ(RBP4)≥70μg.ml-1的比例显著高于无事件组(37.50%比9.30%,P=0.018)。多变量回归分析证实,RBP4水平与1年随访MACEs独立相关联(OR:1.091,95%CI:1.015～1.172,P=0.018)。结论:RBP4水平升高与冠心病及1年预后相关,基线RBP4水平升高者1年主要不良心脏事件风险增加。
Objective: To investigate the relationship between human retinol binding protein 4 (RBP4) level and coronary heart disease and one-year prognosis. Methods: One hundred and forty nondiabetic patients who underwent coronary angiography for suspected coronary artery disease were selected, of whom 94 were diagnosed with coronary heart disease and 46 were non-coronary heart disease as control. Plasma RBP4 levels were measured in 140 patients by ELISA kit (IBL, Germany). Coronary heart disease patients were discharged from the hospital to complete a one-year follow-up, recording major adverse cardiac events (MACEs), recurrent angina, recurrent myocardial infarction, worsening heart failure and cardiac death. Multivariate regression analysis of the relationship between RBP4 and MACEs at 1 year follow up. Results: Compared with the control group, the CHD patients’ hypertension, smoking proportion, age and RBP4 level (51.69 ± 34.96) μg.ml-1 (37.84 ± 15.94) μg.ml-1 were significantly increased or increased All P <0.05). There were 8 cases of MACEs in coronary heart disease group, and the average RBP4 level in the event group was significantly higher than that in the non-event group [(76.12 ± 42.89) μg.ml-1 vs 46.24 ± 17.66 μg.ml-1, P <0.01] The ratio of ρ (RBP4) ≥70μg.ml-1 was significantly higher than that of the non-event group (37.50% vs. 9.30%, P = 0.018). Multivariable regression analysis confirmed that RBP4 levels were independently associated with MACEs at 1-year follow-up (OR: 1.091, 95% CI: 1.015-1.17 2, P = 0.018). CONCLUSIONS: Elevated RBP4 is associated with coronary heart disease and a one-year prognosis, with an increased risk of major adverse cardiac events at 1 year after baseline RBP4 elevation.