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为更好地研究高分解代谢型急性肾功能衰竭,建立了这一疾病的动物模型。SD大鼠分成败血症组、急性缺血性肾功能衰竭组和高分解代谢型急性肾功能衰竭组。败血症模型由腹腔中注入大肠杆菌而制成;急性缺血性肾衰模型采用一侧肾切除及对侧肾动脉夹闭60min而制成;高分解代谢急肾衰模型则在造成大鼠急肾衰同时,从腹腔中注入大肠杆菌而制成。结果表明,高分解代谢急肾衰鼠在术后出现败血症的临床表现,且与败血症和急肾衰组相比,前者的血尿素氮、肌酐、血钾在术后明显增高,而二氧化碳结合力和体重明显下降,死亡率也较高,这符合高分解代谢急肾衰的临床特点,表明所建立的高分解代谢急肾衰模型是可行的。
To better study the acute catabolic renal failure, an animal model of this disease was established. SD rats were divided into sepsis group, acute ischemic renal failure group and high-catabolic acute renal failure group. Sepsis model is made by intraperitoneal injection of Escherichia coli; acute ischemic renal failure model with one side of the nephrectomy and contralateral renal artery occlusion 60min made; hyperlipoidemic model of acute renal failure in rat acute kidney At the same time, from the abdominal cavity into E. coli and made. The results showed that acute renal failure rats with high catabolism showed clinical manifestations of sepsis after operation. Compared with sepsis and acute renal failure group, the blood urea nitrogen, creatinine and serum potassium of the former patients were significantly increased after operation, while carbon dioxide binding And significantly decreased body weight, mortality is also higher, which meets the clinical features of acute renal failure with high catabolism, indicating that established model of acute renal failure with high catabolism is feasible.