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目的通过观察视网膜静脉阻塞患者静脉血中凝血因子Ⅻ(FⅫ)的活性,研究它与视网膜静脉阻塞(RVO)是否相关。方法以随机方式收集我院门诊眼科常规检查眼底正常的正常人25例(25只眼),RVO患者25例(25只眼),按RVO发病年龄分为≤50岁和>50岁两组,根据RVO位置,将RVO病例组分为视网膜中央静脉阻塞(CRVO)、视网膜半侧静脉阻塞(HRVO)、视网膜分枝静脉阻塞(BRVO)三型。所有研究对象均在空腹抽取静脉血2.7ml,一期法测定FXII活性,常规测定凝血功能(APTT)。统计学方法采用Spss13.0软件包,对两组资料采用(Fisher-test)检验与t检验。结果两组资料特征差异(年龄、性别)统计学上无显著性差异(P>0.05);试验组的FXII缺乏发生率虽然比对照组高,但两组比较统计学上差异无显著性(P=0.12),试验组的APTT低于对照组,两组比较统计学上差异有显著性(P=0.02)。结论本研究进一步证实了易栓危险因素(凝血因子Ⅻ)的缺乏与视网膜静脉阻塞的发生、发展之间存在内在的相关性。
Objective To observe the activity of coagulation factor Ⅻ (FⅫ) in venous blood of patients with retinal vein occlusion and investigate whether it is related to retinal vein occlusion (RVO). Methods 25 cases (25 eyes) and 25 eyes (25 eyes) of RVO were randomly divided into two groups: normal control group (n = 50) and RVO group (n = 25) According to RVO location, RVO cases were divided into three groups: central retinal vein occlusion (CRVO), partial retinal vein occlusion (HRVO) and retinal vein branch occlusion (BRVO). All subjects were drawn in fasting blood 2.7ml, a determination of FXII activity, routine determination of coagulation function (APTT). Statistical methods using Spss13.0 package, two sets of data using Fisher-test and t test. Results There was no statistically significant difference between the two groups (P> 0.05). Although the incidence of FXII deficiency in the experimental group was higher than that in the control group, there was no significant difference between the two groups (P = 0.12). The APTT in the experimental group was lower than that in the control group, and the difference was statistically significant (P = 0.02). Conclusions This study further confirms that there is an inherent correlation between the lack of thrombolytic risk factor (clotting factor Ⅻ) and the occurrence and development of retinal vein occlusion.