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目的:为了为临床预防乙型肝炎肝硬化并发自发性细菌性腹膜炎(SBP)提供可靠依据,探讨和研究其发生发展的影响因素以及治疗措施。方法:根据患者住院号先后顺序(2014年6月-2016年6月)选取78例乙型肝炎肝硬化患者作为研究对象,其中包括36例并发自发性细菌性腹膜炎,总结其住院资料并实施统计学分析。结果:单因素研究显示,与乙型肝炎肝硬化非SBP患者相比,SBP患者的血清白蛋白(ALB)、凝血酶原活动度(PTA)、丙氨酸氨基转移酶(ALT)更低,而血清总胆红素(TBIL)、甘油三酯(TG)、消化道出血、便秘/腹泻更高;造成乙型肝炎肝硬化并发SBP的独立危险因素是TBIL、ALB、PTA。结论:乙型肝炎肝硬化以TBIL、ALB、PTA作为并发自发性细菌性腹膜炎的独立危险因素,及早预防上述危险因素有助于减少SBP的发生率,提高患者的生存质量。
Objective: To provide a reliable basis for the prevention of hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis (SBP) in clinic and to explore and study the influencing factors and treatment measures of its occurrence and development. Methods: According to the order of patient’s hospitalization (June 2014-June 2016), 78 patients with hepatitis B cirrhosis were enrolled, including 36 cases of spontaneous bacterial peritonitis, summarizing their hospitalization data and implementing statistics Analysis. RESULTS: In a single-factor study, serum albumin (ALB), prothrombin activity (PTA), and alanine aminotransferase (ALT) were lower in patients with SBP than in non-SBP patients with hepatitis B cirrhosis Serum total bilirubin (TBIL), triglyceride (TG), gastrointestinal bleeding, constipation / diarrhea were higher. The independent risk factors of SBP complicated with hepatitis B cirrhosis were TBIL, ALB and PTA. Conclusion: TBIL, ALB and PTA are independent risk factors for spontaneous bacterial peritonitis in patients with cirrhosis of the liver. Early prevention of these risk factors may reduce the incidence of SBP and improve the quality of life of patients.