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The discovery of the close relationship between inflammation and cancer has been traced back to the 17th century though back then little is known about cells,cytokines and physiological processes that are essential in inflammation and cancers.Chronic-inflammation is a major pathogenic factor in certain types of tumors such as hepatocellular carcinoma,esophageal carcinoma,and gastric carcinoma.Likewise cancers can initiate and maintain local inflammatory processes that may facilitate the proliferation and infiltration of