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日本福崗九州大学医学院外科博士友田和井日两人在1960年1月出版的国际外科学杂志上报告,他们对102名腹腔手术患者成功地应用藻朊酸酮(alginon)——从大的棕色海藻细胞中制取的一种类似胶质的溶液——来代替全血进行输注。应用这种化合物做血液代替品,是因为它与天然血浆一样,是由巨大的蛋白质分子或聚合体所构成的,它能在血管中保持相当时间,注射后70%以上在24小时内排泄出,而不淤积在组织中。友田和井口博士指出,藻肮酸酮比紧急输液时所用的葡萄糖溶液或者盐水好,因为它的化学性质稳
In a January 1960 issue of the International Journal of Surgery, Dr. Tomoda and Inori, chief physicians at Kyushu University School of Medicine in Fukuoka, Japan, reported successful application of alginon to 102 patients with abdominal surgery - A colloid-like solution made in brown seaweed cells instead of whole blood. This compound is used as a blood substitute because it, like native plasma, consists of huge protein molecules or aggregates that remain in the bloodstream for more than 70% of the time that is excreted within 24 hours after injection , But not siltation in the organization. Dr. Tomota and Wellhead noted that alginate is better than the glucose solution or saline used in emergency infusion because of its chemical stability