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目的观察辛伐他汀对糖尿病大鼠种植后血清中骨钙素(BGP)水平及骨密度(BMD)变化的影响。方法选择健康雄性SD大鼠36只,随机分为T0组(正常种植组)12只、T组24只,T组大鼠经腹腔内注射链脲佐菌素建立糖尿病大鼠模型后,在两组大鼠胫骨近骺端植入纯钛种植体,将T组随机分为T1(糖尿病种植组)、T2(辛伐他汀治疗组),每组各12只。术后T0、T1组大鼠给予生理盐水1.5ml.只-1.h-1,T2组给予辛伐他汀5mg.kg-1.d-1灌服,共12W。放射免疫分析法(RIA)进行血清BGP检测;双能X线骨密度仪测量胫骨骨密度(BMD)。结果第12周,T1组血清BGP水平低于T0、T2组,T2组血清BGP水平明显高于T1组,差异有统计学意义(P<0.01),T0组和T2组血清BGP差异无统计学意义(P>0.05);T1组胫骨骨密度水平低于T0、T2组,T2组胫骨骨密度水平明显高于T1组,差异有统计学意义(P<0.01)。结论辛伐他汀可增加糖尿病大鼠骨密度,提高其种植后血清BGP水平,促进成骨。
Objective To observe the effect of simvastatin on serum BGP and bone mineral density (BMD) in diabetic rats. Methods Thirty-six healthy male Sprague-Dawley rats were randomly divided into T0 group (normal group) 12, T group 24, T group rats were intraperitoneally injected with streptozotocin to establish diabetic rat model, Tissue implants were implanted into the proximal tibia of rats. The T group were randomly divided into T1 (diabetic group) and T2 (simvastatin group), with 12 rats in each group. Rats in T0 and T1 groups were treated with saline 1.5ml only -1.h-1, and simvastatin 5mg.kg-1.d-1 was given to rats in T2 group for 12W. Serum BGP was detected by radioimmunoassay (RIA); tibia bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. Results At the 12th week, serum BGP level in T1 group was lower than that in T0 and T2 group. The serum BGP level in T2 group was significantly higher than that in T1 group (P <0.01), but there was no significant difference in BGP between T0 group and T2 group (P> 0.05). The BMD of tibia in T1 group was lower than that in T0 and T2 group. The BMD of tibia in T2 group was significantly higher than that in T1 group (P <0.01). Conclusion Simvastatin can increase the bone mineral density in diabetic rats, increase the level of serum BGP after implantation, and promote osteogenesis.