急性骨髓纤维化

• 作 者: 徐从高 张茂宏
• 机 构: 山东医学院液学研究室,山东医学院液学研究室,
• 出 处: 国外医学.输血及血液学分册
• 发表日期: 1986年01期
• 关键词: 急性骨髓纤维化 骨髓硬化症 骨髓增殖性疾病 幼稚细胞 骨髓增生 细胞化学技术 超微结构观察 巨核细胞 髓样化生 个例报道

急性骨髓纤维化(Acute myclofibrosis,AMF)是一种少见的骨髓增殖性疾病。自1963年Lewis和Szur首次对5例本病患者加以描述以来,文献中陆续有个例报道。对本病是否为一种临床和病理学独立疾病一直存在着争论,文献中命名不一,除急性骨髓纤维化外,尚有急性骨髓硬化症(Acute myelosclerosis),恶性骨髓硬化症(Malignant myelosclerosis),急性巨核细胞性骨髓增生症(Acute megakaryoblastic myelosis)等。有些作者借助于超微结构观察和细胞化学技术,发现该病的幼稚细胞具有巨核细胞系特征,并认为大部份AMF是急性巨核细胞性白血病(Aeute megakaryoblastic leukemia)。1979年Bearman系统复习文献后对该病提出了较为严格的诊断标准。为

Acute myelofibrosis (AMF) is a rare myeloproliferative disease. Since Lewis and Szur first described 5 patients with this disease in 1963, there have been a number of reports in the literature. There is always controversy as to whether this disease is a clinical and pathological independent disease, with different names in the literature, in addition to acute myelofibrosis, acute myelosclerosis, Malignant myelosclerosis, , Acute megakaryoblastic myelosis and the like. With the help of ultrastructural observation and cytochemical techniques, some authors found that naïve cells of this disease have the megakaryocytic lineage characteristics and most of the AMF is believed to be acute megakaryoblastic leukemia. After reviewing the literature in 1979, Bearman system put forward more strict diagnostic criteria for the disease. for