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目的系统评价囊外切除术治疗腮腺良性肿瘤的效果。方法计算机检索Pubmed、Cochrane Library、EMBASE、CNKI、CMCI、VIP、CBM、WANGFANG数据库中关于腮腺囊外切除术治疗腮腺良性肿瘤的文献,由2名评价者独立进行文献质量评价和资料提取后,采用RevMan 5.1软件进行Meta分析。结果共纳入12个研究,ECD组1757例和SP组1006例患者,Meta分析结果显示:ECD术式能降低术后暂时性面瘫(OR=0.16,95%CI:0.08～0.32;P<0.000 01)、味觉出汗综合征发生率(OR=0.10,95%CI:0.06～0.16;P<0.000 01),差异有统计学意义,降低术后永久性面瘫的发生率(OR=0.21,95%CI:0.02～2.20;P=0.19),但差异无统计学意义,两组的术后复发率没有统计学差异(OR=0.61,95%CI:0.32～1.16;P=0.13)。结论 ECD可降低术后暂时性面瘫、味觉出汗综合征发生率,疗效可靠,可作为腮腺良性肿瘤的首选术式。
Objective To systematically evaluate the effect of extracapsular excision on benign parotid tumors. Methods The literature about parotid extracapsular excision in the treatment of benign parotid gland tumor in Pubmed, Cochrane Library, EMBASE, CNKI, CMCI, VIP, CBM and WANGFANG databases was searched by computer. Two reviewers independently evaluated literatures and extracted data. RevMan 5.1 software for meta-analysis. Results A total of 12 studies were enrolled, including 1757 ECD patients and 1006 patients in the SP group. The results of Meta analysis showed that ECD could reduce the postoperative temporary facial paralysis (OR = 0.16, 95% CI: 0.08-0.32; P <0.000 01 ), The incidence of taste sweating syndrome (OR = 0.10, 95% CI: 0.06-0.16; P <0.000 01), the difference was statistically significant, reducing the incidence of postoperative permanent facial paralysis (OR = 0.21, 95% CI: 0.02-2.20; P = 0.19). However, there was no significant difference between the two groups (OR = 0.61,95% CI: 0.32-1.16; P = 0.13). Conclusion ECD can reduce the incidence of postoperative temporary facial paralysis and taste sweat syndrome, and has reliable curative effect. It can be used as the first choice for the treatment of parotid benign tumors.