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目的:通过观察冠心苏合丸系列组方对心脏血流动力学及心肌耗氧量的影响,阐述其对心血管系统的作用。方法:观测冠心苏合丸系列组方对正常麻醉犬动脉血压、冠脉流量、冠脉阻力和总外周阻力、左室做功以及心肌耗氧指数、心肌氧利用率的影响。结果:冠心苏合丸系列组方可明显降低动脉血压,扩张冠脉血管及外周血管,增加冠脉流量,降低冠脉阻力;改善左室做功和心肌氧利用率,调整心脏血管的顺应性。结论:对心血管系统起到调整和改善作用。
Objective: To observe the effect of Guanxin Suhe Pills on cardiac hemodynamics and myocardial oxygen consumption, and to elucidate its effect on cardiovascular system. METHODS: The effects of Guanxin Suhe Pills group on arterial blood pressure, coronary artery flow, coronary resistance and total peripheral resistance, left ventricular work, myocardial oxygen consumption index, and myocardial oxygen utilization rate in normal anesthetized dogs were observed. RESULTS: Guanxin Suhe Pills can significantly reduce arterial blood pressure, dilate coronary vessels and peripheral blood vessels, increase coronary flow and reduce coronary resistance; improve left ventricular work and myocardial oxygen utilization, and adjust cardiovascular compliance . Conclusion: To adjust and improve the cardiovascular system.