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本文采用激素的放射受体分析法和放射免疫测定法分别观察早孕7—9周妇女注射不同剂量的丙酸睾丸酮(丙睾,TP)后,蜕膜组织中孕、雌激素受体含量以及血清促卵泡素(FSH),催乳素(PRL),孕酮(Prog)、雌二醇(E_2)和绒毛膜促性腺激素(HCG)水平的变化,从而进一步探讨丙睾增强前列腺素抗早孕效果的作用机理。研究结果表明,注射丙睾100mg×3天(丙睾Ⅰ组)和100mg×2天(丙睾Ⅱ组),可降低蜕膜组织孕、雌激素核受体含量,但对血清FSH,PRL,Prog,E_2和HCG水平无明显抑制作用。提示丙睾的抗早孕作用可能主要不是通过抑制下丘脑—垂体—卵巢轴,其作用机理之一可能与竞争性抑制蜕膜组织中甾体激素受体有关。
In this paper, hormones radioimmunoassay and radioimmunoassay were observed in the first trimester of pregnancy women were injected with different doses of testosterone propionate (TP, TP), the decidual decidual tissue, estrogen receptor content and serum (FSH), prolactin (PRL), progesterone (Prog), estradiol (E_2) and human chorionic gonadotropin (HCG) levels in order to explore the mechanism of action of enhancing the anti-pregnancy effect of prostaglandin . The results showed that the injection of testosterone 100mg × 3 days (testosterone group Ⅰ) and 100mg × 2 days (testis Ⅱ group) can reduce decidual tissue pregnancy, estrogen nuclear receptor, but the serum FSH, PRL, Prog, E_2 and HCG levels had no significant inhibitory effect. These results suggest that the anti-early pregnancy effect of C may not be mainly through inhibiting the hypothalamic-pituitary-ovarian axis. One of its mechanisms may be related to competitive inhibition of steroid hormone receptors in decidual tissues.