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大量证据表明,慢性高血糖症与糖尿病的慢性微血管病合并症,包括视网膜病变,神经病变与肾病变有密切联系。此外,已证实用胰岛素进行严格的代谢控制可改善其进程。除微血管病并发症外,高血糖症尚与各种其它生理学、生化学和解剖学合并症相关,包括基底膜增厚、大血管病变、蛋白糖基化,细胞免疫能力受损以及各种细胞周期异常。另外,慢性高血糖症对胰岛素分泌和胰岛素作用的损害也日益清楚,从而产生了葡萄糖毒性(glucose toxicity)的概念。据此,高血糖症不仅是糖尿病的表现,而且它本身就是糖尿病状态持久存在的因子。
There is ample evidence that chronic hyperglycemia and diabetic chronic microvascular complications, including retinopathy, neuropathy and nephropathy are closely linked. In addition, strict metabolic control of insulin has been shown to improve its course. In addition to microvascular complications, hyperglycemia is associated with a variety of other physiological, biochemical, and anatomic complications including thickening of the basement membrane, macrovascular disease, glycosylation of proteins, impaired cellular immunity, Abnormal cycle. In addition, damage to insulin secretion and insulin action by chronic hyperglycemia is also becoming increasingly clear, resulting in the concept of glucose toxicity. According to this, hyperglycemia is not only a manifestation of diabetes, but it is also a perpetual factor in the state of diabetes.