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卵巢癌是常见的妇科肿瘤之一,其发病率仅次于子宫内膜癌,致死率却居首位[1]。卵巢癌早期症状隐匿,诊断时多已有转移。资料显示,按照国际妇产科联合会(FIGO)肿瘤分期标准分期的Ⅰ、Ⅱ期卵巢癌患者5年生存率为70%~90%,而Ⅲ、Ⅳ期患者5年生存率仅为27%[1]。转移是影响卵巢癌患者生存期的重要因素,已成为研究的热点和难点。现将卵巢癌转移相关分子标记的研究综述如下。
Ovarian cancer is one of the common gynecological tumors, the incidence of which is second only to endometrial cancer, but the mortality rate ranks first [1]. Early symptoms of ovarian cancer hidden, when the diagnosis has been more than the transfer. According to the data, the 5-year survival rates of patients with stage I and II ovarian cancer staging according to the International Union of Gynecology and Obstetrics (FIGO) staging systems are 70% -90%, while the 5-year survival rates of stage III and IV patients are only 27% [1]. Metastasis is an important factor affecting the survival of patients with ovarian cancer has become a hot and difficult point of study. The ovarian cancer metastasis-related molecular markers are summarized below.