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用乙二醇法诱导大鼠产生草酸钙结石，用45~Ca示踪测定法了解中草药复方制剂（PESM）对草酸钙结石形成的抑制作用。结果显示，实验组肾脏放射性强度明显减少（实验组3.47±3.52cpm／mg，对照组10.89±14.24cpm／mg）。干肾重量明显下降（实验组306.0±47.0mg，对照组343.1±59.4mg），说明PESM能明显抑制肾脏草酸钙结石的形成。
The calcium oxalate stones were induced by ethylene glycol in rats. The inhibitory effect of PESM on the formation of calcium oxalate stones was observed by 45 ~ Ca tracing assay. The results showed that the experimental group, renal radioactivity was significantly reduced (experimental group 3.47 ± 3.52cpm / mg, the control group 10.89 ± 14.24cpm / mg). The weight of dry kidney decreased significantly (experimental group 306.0 ± 47.0mg, control group 343.1 ± 59.4mg), PESM can significantly inhibit the formation of kidney calcium oxalate stones.