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为确定胎盘ＴＧＦ－β的分布，探讨ＰＩＨ胎盘ＴＧＦ－β表达有无异常，用免疫组织化学染色观察了１０例早孕绒毛、１４例正常孕妇、４１例ＰＩＨ胎盘ＴＧＦ－β的分布。发现早孕绒毛滋养层细胞ＴＧＦ－β染色强阳性；晚孕期染色较早孕期显著减弱；绒毛外滋养层细胞ＴＧＦ－β阳性。ＰＩＨ患者绒毛滋养层细胞ＴＧＦ－β表达降低，且与病情程度相关。率先表明滋养层细胞存在ＴＧＦ－β的自分泌与旁分泌，ＴＧＦ－β表达受抑可能与ＰＩＨ发病有关。
In order to determine the distribution of TGF-β in placenta, the expression of TGF-β in placenta of PIH was investigated. The distribution of TGF-β in 10 cases of PIH placenta was observed by immunohistochemical staining. Found that early trophoblast trophoblast TGF-β staining strong positive; late pregnancy significantly weakened during the first trimester of pregnancy; villous trophoblast TGF-β-positive. PIH patients trophoblast cells TGF-β expression decreased, and with the severity of the disease. The first to show trophoblast cells exist TGF-β autocrine and paracrine, inhibition of TGF-β expression may be related to the pathogenesis of PIH.