论文部分内容阅读
目的 :探讨bcl 2和p5 3在胃癌的表达。方法 :应用免疫组化检测 78例胃癌中bcl 2、p5 3的表达情况。结果 :bcl 2和p5 3在胃癌中的表达率分别为 4 2 .3%和 5 2 .4 % ,bcl 2和 p5 3蛋白表达与胃癌分化程度、浸润深度、淋巴结转移及临床分期均无明显关系 ,bcl 2和p5 3表达之间存在相关性 (P <0 .0 1)。结论 :凋亡相关基因bcl 2和p5 3的异常表达在胃癌发生中起重要作用
Objective: To investigate the expression of bcl-2 and p5 3 in gastric cancer. Methods: The expression of bcl 2 and p 5 3 in 78 cases of gastric cancer was detected by immunohistochemistry. Results: The expressions of bcl-2 and p53 in gastric cancer were 42.3% and 52.4% respectively. There was no significant difference in the expression of bcl-2 and p53 protein between the expression of bcl-2 and p53 in gastric cancer, the depth of invasion, lymph node metastasis and clinical stage There was a correlation between the expression of bcl-2 and p5 (P <0.01). Conclusion: Aberrant expression of apoptosis related genes bcl 2 and p 5 3 plays an important role in the development of gastric cancer