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阿斯匹林是具耳毒性作用的药物。临床研究一般认为系可逆性,听力可全频率减退,对高频或更为敏感。耳鸣常出现于耳聋前,很少出现不稳感,血清水扬酸浓度常在200～450mg/L。但一些作者研究的结果颇有分歧,提出病变部位在毛细胞、或螺旋神经节细胞,或血管纹水扬酸浓度增高。Mitchell(1973)发现其影响AP,为可逆性,不影响CM;Silverstein(1967)则认为可使CM振幅降低。本文报道2例急性水扬酸过量病例,于用利尿剂之前,当时及以后测定纯音听阈、耳蜗电图、血清含量。例1为入院前4小时服阿斯匹林100片,诉耳鸣、耳聋、不稳感。血清水扬酸606mg/L,
Aspirin is an ototoxic drug. Clinical research is generally considered Department of reversibility, hearing can be the full frequency of decline, or more sensitive to high-frequency. Tinnitus often occurs before deafness, seldom instability, serum salicylic acid concentration often in the 200 ~ 450mg / L. However, the results of some authors’ studies are quite different and suggest that the lesion site has an increased concentration of hair cells, or spiral ganglion cells, or vasculogenic acid. Mitchell (1973) found that AP affects reversibility and does not affect CM; Silverstein (1967) is believed to reduce CM amplitude. This article reports two cases of acute salicylic acid overdose, before diurnal use, then and after the pure tone audiometry, cochlear electrogram, serum content. Example 1 4 hours before admission admission aspirin 100, v. Tinnitus, deafness, instability. Serum salicylic acid 606mg / L,