论文部分内容阅读
在24条急性开胸犬上,通过微米狭窄器造成冠脉左旋支不同程度的狭窄。临界狭窄以阻断冠脉血流15秒后放松冠脉、不再发生反应性充血为准;重度狭窄以心电图出现ST段抬高。临界狭窄时,冠脉横截面积减少88％,冠脉血流量(CBF)、外周小冠脉压(Pc)、左心室收缩峰压(LVSP)和左心室压力最大上升速率(dp/dtmax)都降低。重度狭窄时,冠脉横截面积减少91％,CBF、Pc、LVSP和dp/dtmax进一步下降,主动脉压(Pa)和左心室压力最大下降速率降低,左心室舒张压(LVDP)及冠脉阻力(R)增加。在临界狭窄程度以上,CBF与LVSP呈正相关。冠脉狭窄引起的这些变化可部分解释冠心病人心脏功能的变化。
In 24 acute thoracodorsal dogs, coronary stenosis caused by varying degrees of stenosis through the micrometer stenosis. Critical stenosis to prevent coronary blood flow after 15 seconds to relax the coronary artery, reactive hyperemia prevail prevail; severe stenosis with ECG ST segment elevation. At the critical stenosis, coronary cross-sectional area decreased by 88%, coronary flow (CBF), peripheral small coronary pressure (Pc), left ventricular systolic pressure (LVSP) and left ventricular pressure (dp / dtmax) Are lower. Severe stenosis, coronary cross-sectional area decreased 91%, CBF, Pc, LVSP and dp / dtmax further decreased, aortic pressure (Pa) and decreased maximum rate of left ventricular pressure, left ventricular diastolic pressure (LVDP) Resistance (R) increases. Above the critical stenosis, CBF was positively correlated with LVSP. These changes caused by coronary stenosis can partially explain the changes in cardiac function in patients with coronary heart disease.