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年龄相关性黄斑变性(age-related macular degeneration,AMD)是老年人致盲的主要原因。关于 AMD的发病机制最近有研究表明,其发病与免疫炎症反应关系密切。本文就炎症介质合成与分泌、补体系统、免疫相关细胞与炎症细胞等方面探讨 AMD 与免疫炎症反应的关系。
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Recent studies on the pathogenesis of AMD show that its pathogenesis is closely related to immune and inflammatory reactions. This article explores the relationship between AMD and immune inflammatory response in terms of inflammatory mediators synthesis and secretion, complement system, immune-related cells and inflammatory cells.