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目的分析阿司匹林联合氯吡格雷治疗短暂性脑缺血发作(TIA)临床效果。方法选取2012年7月—2016年3月安阳市人民医院收治的88例短暂性脑缺血发作患者,采用随机数字表法分为观察组(44例)和对照组(44例),两组均给予阿司匹林治疗,观察组加用氯吡格雷治疗,治疗12周后统计对比两组总有效率、不良反应发生率。结果观察组总有效率95.45%(42/44)高于对照组79.55%(35/44),差异具有统计学意义(χ~2=5.091,P<0.05);观察组不良反应发生率6.82%(3/44)与对照组2.27%(1/44)相比,差异无统计学意义(χ~2=0.262,P>0.05)。结论短暂性脑缺血发作以氯吡格雷和阿司匹林联合治疗,可减少疾病发作次数,提高疗效,可行性高。
Objective To analyze the clinical effect of aspirin combined with clopidogrel in the treatment of transient ischemic attack (TIA). Methods 88 patients with transient ischemic attack admitted to Anyang People’s Hospital from July 2012 to March 2016 were randomly divided into observation group (44 cases) and control group (44 cases) Were given aspirin treatment, the observation group plus clopidogrel treatment, 12 weeks after treatment statistics were compared the two groups of total effective rate, the incidence of adverse reactions. Results The total effective rate in observation group was 95.45% (42/44), which was significantly higher than that in control group (79.55%, 35/44) (χ ~ 2 = 5.091, P <0.05). The adverse reaction rate in observation group was 6.82% (3/44) compared with control group 2.27% (1/44), the difference was not statistically significant (χ ~ 2 = 0.262, P> 0.05). Conclusions Transient ischemic attack combined with clopidogrel and aspirin can reduce the frequency of disease onset and improve the curative effect, with high feasibility.