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本文旨在验证survivin基因在预测膀胱尿路上皮癌预后中的作用,实验在多个机构行膀胱根治性切除术的患者队列中外部验证。本研究共纳入行膀胱根治性切除术和双侧盆腔淋巴结清扫的患者726例,使用免疫组化对手术切除的肿瘤标本染色,并利用颜色检测软件自动进行survivin显色的评分。样品显色超过10%时定义为阳性。使用K-M法和COX回归进
The aim of this study was to verify the role of survivin in predicting the prognosis of bladder urothelial carcinoma. The experiment was externally validated in a cohort of patients undergoing radical cystectomy. In our study, 726 patients undergoing radical cuff resection and bilateral pelvic lymph node dissection were enrolled. The tumor specimens were excised with immunohistochemistry and the colorimetric software was used to automatically detect the expression of survivin. Positive samples were defined as more than 10% color developed. Use K-M method and COX regression