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目的探讨利用综合方法治疗耐多药肺结核的临床疗效。方法对 3 3例耐多药肺结核 (MDR PTB)患者选用合理抗痨方案 ,给予全身治疗的同时采用介入方法局部用药 ,并配合免疫治疗手段进行综合治疗。结果 1个月内 3 3例症状均得到明显缓解 ,全身情况好转 ,6个月内 2 4例病灶明显吸收好转 ,18例空洞患者中有 6例闭合 ,6例缩小 ,无一例病灶增大。痰涂片 3个月内 2 7例阴转 ,痰培养 4个月内 2 8例阴转 ,5例持续阳性。结论MDR PTB单靠化疗方案的调整效果有限 ,而利用现有的技术手段进行综合治疗的疗效肯定
Objective To explore the clinical efficacy of multidrug-resistant pulmonary tuberculosis using an integrated approach. Methods A total of 33 patients with multidrug-resistant pulmonary tuberculosis (MDR PTB) were enrolled in this study. The patients were treated with systemic anti-tuberculosis drugs by local intervention and combined with immunotherapy. Results All the patients were relieved of their symptoms in 3 months. The systemic condition improved. 24 cases showed obvious improvement in 6 months. Among the 18 cases, 6 cases were closed, 6 cases were reduced, and none was increased. 27 cases of sputum smear negative conversion within 3 months, sputum culture within 4 months 28 cases of negative, 5 cases of persistent positive. Conclusion The adjustment effect of MDR PTB alone on chemotherapy regimen is limited, and the curative effect of comprehensive treatment by using the existing technical means is certainly