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耐药结核分歧杆菌较敏感结核分歧杆菌有更高的致死率和发病率[1]。通过检测结核分歧杆菌(MTB)的耐药基因是否发生突变,可以推断MTB的耐药性。常用的耐药基因检测技术有基因芯片技术、DNA测序技术、PCR-单链构象多态性分析(PCR-SSCP)技术。晶芯试剂盒是利用基因芯片技术对临床常见的结核分歧杆菌的INH耐药基因kat G、inh A和RFP耐药基因rop B进行
Drug-resistant Mycobacterium tuberculosis sensitive Mycobacterium tuberculosis have a higher mortality and morbidity [1]. The resistance of MTB can be inferred by detecting whether there is a mutation in the drug resistance gene of Mycobacterium tuberculosis (MTB). Commonly used drug resistance gene detection technology has gene chip technology, DNA sequencing technology, PCR-single strand conformation polymorphism analysis (PCR-SSCP) technology. Crystal core kit is the use of gene chip technology for clinical common Mycobacterium tuberculosis INH resistance gene kat G, inh A and RFP resistance gene rop B