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非甾体类抗炎药(NSAID′S)用于风湿性炎症的治疗,在临床上日渐增多,尽管此类药物属非特异性治疗药物,但却可明显改善症状和减轻炎症反应,延缓活动期病变的发展。目前对此类药物的作用机理虽尚未完全弄清,然而大量资料表明NSAID′S的抗炎作用、退热作用、止痛作用及某些毒性作用都与抑制前列腺素的生物合成有关。本文着重介绍阿斯匹林、消炎痛等NSAID′S的抗炎、止痛、退热作用以及某些毒性反应
Non-steroidal anti-inflammatory drugs (NSAID’S) are used in the treatment of rheumatic inflammation, and they are gradually increasing in clinical practice. Although these drugs are non-specific therapeutic drugs, they can significantly improve the symptoms and reduce the inflammatory response and delay the active period. The development of lesions. Although the mechanism of action of these drugs is not fully understood, a large number of data indicate that the anti-inflammatory effects, antipyretic effects, analgesic effects and certain toxic effects of NSAID’s are related to the inhibition of prostaglandin biosynthesis. This article focuses on the anti-inflammatory, analgesic, antipyretic and some toxic effects of NSAID’S such as aspirin, indomethacin, etc.