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对于肝硬化食道胃底静脉曲张出血过去常采用小剂量垂体后叶素经静脉治疗,疗效多不满意。近年来已陆续有文献报道,大剂量垂体后叶素加酚妥拉明联合治疗食道胃底静脉曲张出血疗效满意,笔者经有关文献复习于近几年来试用大剂量垂体后叶素加酚妥拉明联合治疗食道胃底静脉曲张出血27例,经临床对照观察,其疗效显著。 1 材料和方法 病例选择:53例患者均有典型肝硬化门静脉高压的临床表现并伴有腹水、低白蛋白血症,其中7例有轻度黄疸,一例合并原发性肝癌。上述患者均经纤维胃镜证实为食道胃底静脉曲张破裂出血,有冠心病、高血压史、孕妇、急性出血伴有急性肾功能衰竭早期,在血容量朱充分纠正之前为治疗之禁忌症。53例患者随机分为两组即大剂量垂体后叶素加酚妥拉明组(以下简称治疗组),和单用垂体后叶素组(以下简称对照组)。治疗组27例,男22例,女5例,平均年龄51.5岁;对照组26例,男20例。女6例,平均年
For cirrhosis of esophageal varices bleeding in the past often used a small dose of vasopressin after intravenous therapy, the effect is not satisfied. In recent years, one after another have been reported in the literature, large doses of pituitrin and phentolamine combined treatment of esophageal varices bleeding is satisfactory, the author review of the literature in recent years to try large doses of pituitrin and phentola Ming combined treatment of esophageal and gastric variceal bleeding in 27 cases, the clinical observation, the effect was significant. 1 Materials and Methods Case Selection: 53 patients with typical clinical manifestations of portal hypertension and cirrhosis accompanied by ascites, hypoalbuminemia, including 7 cases of mild jaundice, a case of primary liver cancer. The above patients were confirmed by fiber endoscopy esophageal variceal bleeding, with coronary heart disease, history of hypertension, pregnant women, acute hemorrhage accompanied by early acute renal failure, adequate correction of blood volume Zhu for the treatment of contraindications. Fifty-three patients were randomly divided into two groups: high-dose pituitrin plus phentolamine group (hereinafter referred to as treatment group), and pituitrin alone group (hereinafter referred to as the control group). The treatment group of 27 cases, 22 males and 5 females, mean age 51.5 years; control group of 26 patients, 20 males. 6 females, average years