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为探讨喉癌变过程中 Ｃｙｃｌｉｎ Ｄ１ 和 Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１表达的临床病理学意义，用免疫组化检测２０ 例正常粘膜、４０ 例不典型增生病变和 ６０ 例喉癌组织中 Ｃｙｃｌｉｎ Ｄ１ 和 Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１的表达。结果是：（１） Ｃｙｃｌｉｎ Ｄ１ 和 Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１阳性表达定位于细胞核；（２）在喉癌变过程中，喉正常粘膜、不典型增生病变和喉癌中 Ｃｙｃｌｉｎ Ｄ１ 阳性表达率分别为 ５．０％ （１／２０），３０．０％ （１２／４０），５３．３％ （３２／６０）（ Ｐ＜ ０．００１）； Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１阳性表达率分别为９５．０％ （１９／２０），７５．０％ （３０／４０）和 ６３．３％ （３８／６０）（ Ｐ＜ ０．０５）；（３） Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１在高、中、低分化的喉癌中阳性表达率分别为 ７６２％ （１６／２１），６５．５％ （１９／２９）和 ３０．０％ （３／１０）（ Ｐ＜ ００５）； Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１阳性表达与肿瘤细胞的分化有关；（４） Ｃｙｃｌｉｎ Ｄ１ 和 Ｐ２１ Ｗ Ａ Ｆ Ｉ／ Ｃ Ｉ Ｐ１阳性表达显著相关。表明：（１）喉癌变过程中 Ｃｙｃｌｉｎ Ｄ１ 阳性表?
To investigate the clinicopathological significance of the expression of Cyclin D1 and P21 W A F I / C I P1 during laryngeal carcinogenesis, the expression of Cyclin D1 in 20 cases of normal mucosa, 40 cases of atypical hyperplasia and 60 cases of laryngeal carcinoma were detected by immunohistochemistry And P21 W A F I / C I P1 expression. The results were as follows: (1) The positive expression of Cyclin D1 and P21 W A F I / C I P1 localized in the nucleus; (2) The positive rate of Cyclin D1 expression in laryngeal normal mucosa, atypical hyperplasia lesions and laryngeal carcinoma (P <0.001). The positive rates of P21 W A F I / C I P1 were 5.0% (1/20), 30.0% (12/40) and 53.3% (32/60) Rates were 95.0% (19/20), 75.0% (30/40), and 63.3% (38/60) respectively (P <0.05); (3) P21W A F I / C The positive rates of I P1 in high, moderate and poorly differentiated laryngeal cancer were 76.2% (16/21), 65.5% (19/29) and 30.0% (3/10), respectively (P < 005). The positive expression of P21 W A F I / C I P1 was related to the differentiation of tumor cells. (4) The expression of Cyclin 1 and P21 W A F I / C I P1 significant positive correlation. Show: (1) laryngeal carcinogenesis Cyclin D1 positive form?