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用抗p53单克隆抗体Do-7河检测68例膀胱移行上皮细胞癌．总阳性率44．1％16（30／68）。病理分级G_1p53阳性事28．6％（8／28）．G_248％（12／25），G_366．7％（10／15）（P＜0．05）。浸润型膀胱癌（T_2～T_4）的p53阳性率61．3％（19／31）．显著高于钱表型膀胱癌（Ta～T1）的29．7％（11／37）（P＜0．01）。随访材料（中位时间79个同）提示；p53阳性病例有很高的复发（P＜0．05〕、转移（P＜0．01）比例和较低的存活概率（P＜0．01）、本研究表明：膀恍癌p53过度表达与肿瘤恶性生物学行为密切相关，p53异常蛋白的检测可能是临床上有实用价值的客观预后指标。
68 cases of transitional cell carcinoma of the bladder were detected by Do-7 River with anti-p53 monoclonal antibody. The total positive rate of 44.1% 16 (30/68). The pathological grading G_1p53 was positive in 28.6% (8/28). G_248% (12/25), G_366.7% (10/15) (P <0.05). The positive rate of p53 in invasive type bladder cancer (T 2 ~ T 4) was 61.3% (19/31). Which was significantly higher than 29.7% (11/37) (P <0.01) of money-table bladder cancer (Ta ~ T1). There was a high recurrence rate (P <0.05), the proportion of metastasis (P <0.01) and the low survival probability (P <0.01) The present study shows that p53 overexpression in bladder cancer is closely related to the malignant biological behavior of the tumor, and the detection of p53 abnormal protein may be an objective prognostic indicator of clinical utility.