论文部分内容阅读
某些血液病,如急性白血病、恶性淋巴瘤病程中,乳酸酸中毒可以是致死性的代谢合并症,死亡率可高达60～90%。本症尚未受到应有的重视。兹就有关问题综述如下。一、发病机理 Field于1963年首次报告8例急性白血病并发乳酸酸中毒。1966年该作者又报告13例造血系统肿瘤(其中急性白血病10例,淋巴瘤2例,多发性骨髓瘤1例)并发乳酸酸中毒。此后陆续有文献报道。有关发病机理,各有异同,主要有以下几种: (一)组织缺氧,无氧糖酵解亢进,乳酸产生增多 Field报告的13例中,7例严重乳酸酸
In some blood diseases, such as acute leukemia and malignant lymphoma, lactic acidosis can be fatal metabolic complications, the mortality rate can be as high as 60-90%. The disease has not been given due attention. Here is a summary of the relevant issues. First, the pathogenesis Field in 1963 for the first time reported 8 cases of acute leukemia complicated by lactic acidosis. In 1966, the author reported 13 cases of hematopoietic tumors (including 10 cases of acute leukemia, 2 cases of lymphoma, 1 case of multiple myeloma) complicated by lactic acidosis. Since then there have been reports in the literature. The pathogenesis, there are similarities and differences, there are the following: (a) hypoxia, anaerobic glycolysis hyperthyroidism, increased production of Lactate Field reported 13 cases, 7 cases of severe lactic acid