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目的:研究赤芝孢子粉提取物肠溶滴丸灌胃给药后对大鼠的镇静催眠作用。方法:采用阈上和阈下剂量戊巴比妥钠、致大鼠睡眠的方法,考察不同剂量、不同给药方式下赤芝孢子粉提取物对大鼠睡眠时间及主动活动等的影响。结果:采用阈上剂量戊巴比妥钠诱导大鼠催眠作用表明,灌胃孢子粉肠溶滴丸1.5及2.5g/kg,可明显延长睡眠时间(p<0.01);采用阈下剂量戊巴比妥钠诱导大鼠催眠作用表明,灌胃孢子粉肠溶滴丸1.5及2.5g/kg,可明显延长睡眠时间(p<0.05),与皮下同剂量注射给药相比无显著性差异。结论:赤芝孢子粉提取物肠溶滴丸剂对于大鼠具有镇静催眠作用。
Objective: To study the sedative and hypnotic effects of ganoderma lucidum spore powder extract enteric-dripping pills administered intragastrically in rats. Methods: The rats were anesthetized by top and subthreshold doses of pentobarbital sodium, and the effects of different doses of Ganoderma lucidum spores extract on the sleep time and active activities of rats were investigated. Results: The hypnotic effect induced by pentobarbital sodium in the suprathreshold dose group showed that 1.5 and 2.5 g / kg of spore powder enteric dripping pills could significantly prolong the sleep time (p <0.01) Sodium hypnotic effect induced by sodium showed that gavage spore powder enteric dripping pills 1.5 and 2.5g / kg, can significantly prolong sleep time (p <0.05), and subcutaneous injection of the same dose was no significant difference. Conclusion: Ganoderma lucidum spore powder extract enteric dripping pills have sedative and hypnotic effects on rats.