论文部分内容阅读
目的:观察中药组方对老年非小细胞肺癌化疗所致骨髓抑制的改善作用。方法:将我院2010年5月-2013年9月接诊的96例老年非小细胞肺癌患者作为研究对象,随机分为对照组(45例)和中药组(51例),对照组采用GP(吉西他滨+顺铂)方案化疗,治疗组在对照组方案的基础上服用加味参苓白术散。比较两组患者治疗前后白细胞、粒细胞、血小板、血红蛋白水平的变化。结果:化疗14天后中药组患者出现Ⅱ度及以上的白细胞、粒细胞减少的发生率均明显低于对照组(P<0.05)。中药组与对照组相比,治疗组各周期发生Ⅱ度及以上骨髓抑制的例数、发生率及化疗按时完成率均显著优于对照组(P<0.05)。结论:中西医结合治疗方案对老年非小细胞肺癌化疗患者的骨髓抑制具有明显的改善作用。
Objective: To observe the effect of traditional Chinese medicine on bone marrow suppression induced by chemotherapy in elderly patients with non-small cell lung cancer. Methods: A total of 96 elderly NSCLC patients admitted from May 2010 to September 2013 in our hospital were randomly divided into the control group (n = 45) and the traditional Chinese medicine group (n = 51). The control group received GP (Gemcitabine plus cisplatin) regimen chemotherapy, the treatment group in the control group based on the program to take Modified Shenling Baizhu San. The changes of leukocyte, granulocyte, platelet and hemoglobin in two groups before and after treatment were compared. Results: After 14 days of chemotherapy, the incidence of leukopenia and neutropenia in Chinese medicine group was significantly lower than that in control group (P <0.05). Compared with the control group, the number of cases of myelosuppression in grade Ⅱ and above in the treatment group, the incidence and the completion rate of chemotherapy were significantly better than those in the control group (P <0.05). Conclusion: The combination of traditional Chinese and Western medicine treatment of elderly patients with non-small cell lung cancer chemotherapy has significantly improved myelosuppression.