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目的研究不同时期慢性肾脏病(CKD)患者脉搏波速度(PWV)值的变化特点及其与血清胱抑素(Cys-C)和栓塞性心脑血管疾病(CVD)的关系,探论其临床意义。方法采用脉搏波速度测定仪,测定江苏省淮安市第二人民医院住院或门诊61例慢性肾脏疾病患者及30例正常人的PWV值。结果61例慢性肾脏疾病患者其PWV值异常率高达88.5%,为正常组的13.4倍,P<0.01,并且PWV增快伴血清胱抑素升高或内生肌酐清除率的降低有明显的相关性,p<0.01。结论随着慢性肾脏病病程进展,肾功能减退普遍存在主动脉僵硬度增加,弹性下降。PWV明显增快,说明肾功能损害的程度与其明显相关;CKD患者PWV加快可能与其CVD有关。
Objective To investigate the changes of pulse wave velocity (PWV) in patients with chronic kidney disease (CKD) at different stages and its relationship with serum cystatin C (Cys-C) and thrombotic cardiovascular and cerebrovascular diseases (CVD) significance. Methods The PWV values of 61 patients with chronic kidney disease and 30 normal people in hospital or outpatient department of Second People ’s Hospital of Huaian City, Jiangsu Province were determined by pulse wave velocity analyzer. Results The abnormal rate of PWV in 61 patients with chronic kidney disease was 88.5%, which was 13.4 times of that in normal group (P <0.01), and the PWV increased with the increase of serum cystatin or the decrease of endogenous creatinine clearance Sex, p <0.01. Conclusion With the progress of chronic kidney disease, renal insufficiency generally increases aortic stiffness and elasticity. PWV significantly increased, indicating that the extent of renal damage and its significant correlation; CKD patients with accelerated CVD may be related to CVD.