【摘 要】
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Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia.NS1\',a 52-amino acid C-terminal extension of NS 1,is generated with a-1 programmed ribosomal frameshift and is only present in members of the
【机 构】
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State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University, Wuhan 430070, Ch
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Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia.NS1\',a 52-amino acid C-terminal extension of NS 1,is generated with a-1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses.Previous studies demonstrated that NS 1\'plays a vital role in virulence,but the mechanism is unclear.In this study,an NS1\'defected (rG66A) virus was generated.We found that rG66A virus was less virulent than its parent virus (pSA14) in wild-type mice.However,similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model.Moreover,we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14,and JEV NS1\'significantly inhibited the production of IFN-β and IFN-stimulated genes.Taken together,our results reveal that NS1\'plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication.
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