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随着生活水平的提高,生活方式的改变,饮酒人数的增加,酒精性肝病(alcoholic liver disease,ALD)和肥胖导致的非酒精性肝病是仅次于病毒性肝炎的第二大类肝病,已成为比较严重的公共社会问题[1-2]。90%进入体内的酒精在肝内代谢,正常人每日可代谢120g酒精,长期饮酒使肝细胞反复发生脂肪变性、坏死和再生,最终引起ALD。ALD临床可分为酒精性脂肪肝、酒精性肝炎和酒精性肝硬化。大多数单纯酒精性脂肪肝患者,尤其年轻者,没有症状。10%~20%的酗酒者均有不同程度的ALD。慢性丙型肝炎(chronic hepatitis C,
With the improvement of living standards, lifestyle changes, increased drinking, alcoholic liver disease (ALD) and obesity-induced non-alcoholic liver disease is second only to viral hepatitis, the second largest category of liver disease has Become more serious public social problems [1-2]. 90% into the body of alcohol metabolism in the liver, normal daily metabolism of 120g of alcohol, long-term alcohol consumption of liver cells repeatedly fat denaturation, necrosis and regeneration eventually lead to ALD. ALD clinical can be divided into alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Most patients with alcoholic fatty liver, especially young people, have no symptoms. 10% to 20% of alcoholics have different degrees of ALD. Chronic hepatitis C (chronic hepatitis C,