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目的探讨无创呼吸机治疗矽肺伴Ⅱ型呼吸衰竭的临床疗效。方法选取2010年6月至2013年1月于涟源市人民医院就诊的矽肺伴Ⅱ型呼吸衰竭患者67例,分为治疗组(采用无创呼吸机治疗)34例和对照组33例,观察两组患者治疗前与治疗后24 h心率、呼吸变化,并记录pH值、动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、血氧饱和度(SaO2)等各指标的变化。结果两组患者治疗后心率、呼吸与治疗前比较显著下降,差异有统计学意义(P<0.05);治疗组与对照组治疗后比较,差异有统计学意义(P<0.05)。pH值、PaCO2、PaO2、SaO2等各指标,两组患者治疗后与治疗前比较,差异有统计学意义(P<0.05);治疗组与对照组治疗后比较,差异有统计学意义(P<0.05)。患者不良反应轻微,经对症处理后好转。结论早期应用无创呼吸机治疗矽肺合并呼吸衰竭患者,可显著改善患者的临床症状和动脉血气,减慢心率,并能降低气管插管的使用率,值得临床进一步推广应用。
Objective To investigate the clinical efficacy of noninvasive ventilator in the treatment of silicosis Ⅱ respiratory failure. Methods Sixty-seven patients with silicosis Ⅱ respiratory failure who were treated in Lianyuan People’s Hospital from June 2010 to January 2013 were selected and divided into treatment group (noninvasive ventilator-treated) 34 cases and control group 33 cases The changes of heart rate, respiration and the changes of pH, arterial carbon dioxide (PaCO2), PaO2 and SaO2 were observed before treatment and 24 h after treatment. Results After treatment, heart rate and respiration decreased significantly in both groups (P <0.05). The difference between the two groups was statistically significant (P <0.05). pH, PaCO2, PaO2, SaO2 and other indicators, the two groups of patients after treatment compared with before treatment, the difference was statistically significant (P <0.05); treatment group and control group after treatment, the difference was statistically significant (P < 0.05). Minor adverse reactions in patients improved after symptomatic treatment. Conclusion The early application of non-invasive ventilator in patients with silicosis and respiratory failure can significantly improve the patient’s clinical symptoms and arterial blood gas, heart rate, and can reduce the rate of endotracheal intubation, worthy of further clinical application.