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目的探讨血清胱抑素C、β2-微球蛋白及传统标志物(Cr、BUN和UAc)在肾功能不同损害期尤其是早期肾功能损害检测中的临床应用价值。方法选择100例不同病程肾功能损害门诊和住院病人,100例健康体检者作为对照组。用全自动生化分析仪检测血清CysC、β2-MG、Cr、BUN和UAc。结果与对照组相比,血清CysC、β2-MG差异有统计学意义(P<0.01),而血清Cr、BUN和UAc在肾功能损害的早期无临床症状组比较中,差异无统计学意义(P>0.05)。血清CysC、β2-MG联合检测时阳性率较单项检测明显提高,可达92.3%。结论血清CysC、β2-MG比Cr、BUN、UAc能更敏感,准确反映肾小球滤过率(GFR),联合检测对早期诊断肾功能损害具有重要临床价值。
Objective To investigate the clinical value of serum cystatin C, β2-microglobulin and traditional markers (Cr, BUN and UAc) in the detection of different renal damage, especially early renal damage. Methods 100 outpatients and inpatients with different stages of renal dysfunction were selected and 100 healthy subjects were selected as the control group. Serum CysC, β2-MG, Cr, BUN and UAc were detected by automatic biochemical analyzer. Results Compared with the control group, the serum CysC and β2-MG levels were significantly different (P <0.01), while the serum levels of Cr, BUN and UAc were not significantly different in the early stage of renal dysfunction without clinical symptoms P> 0.05). Serum CysC, β2-MG combined detection of positive rate was significantly higher than the single test, up to 92.3%. Conclusions Serum CysC and β2-MG are more sensitive than Cr, BUN and UAc, and accurately reflect glomerular filtration rate (GFR). Combined detection has important clinical value in early diagnosis of renal damage.