论文部分内容阅读
目的探讨原发性宫颈大细胞神经内分泌癌的临床病理特征和免疫表型。方法对1例宫颈大细胞神经内分泌癌进行组织病理学观察和免疫组化检测,复习临床资料和相关文献。结果本例宫颈大细胞神经内分泌癌临床表现为阴道不规则出血伴宫颈肿物。镜下见肿瘤细胞排列呈器官样结构,瘤细胞比小细胞癌大,细胞呈多角形,核大、胞质少,核染色质粗,核仁明显,核分裂活跃。局部可见坏死。免疫组化:肿瘤细胞Syn、CD56和CK8(+),CK5/6、CD10、CD15、desmin、S-100、CD20、vimentin、CD3、p53、SMA、D2-40、HMB45和TTF-1(-)。结论宫颈大细胞神经内分泌癌是一种罕见的高度恶性肿瘤,需与宫颈低分化鳞状细胞癌、低分化腺癌、类癌、不典型类癌、小细胞癌及其他肿瘤鉴别。
Objective To investigate the clinicopathological features and immunophenotypes of primary cervical cancer with neuroendocrine carcinoma. Methods One case of cervical intracerebral neuroendocrine carcinoma was observed by histopathology and immunohistochemistry. The clinical data and related literatures were reviewed. Results of this case of cervical macrophage neuroendocrine cancer clinical manifestations of irregular vaginal bleeding with cervical mass. Microscopically, tumor cells were arranged in organ-like structure. The tumor cells were larger than small cell carcinoma. The cells were polygonal with large nucleus, few cytoplasm, coarse nuclear chromatin, obvious nucleoli and active mitotic activity. Local visible necrosis. Immunohistochemistry: The tumor cells Syn, CD56 and CK8 (+), CK5 / 6, CD10, CD15, desmin, S-100, CD20, vimentin, CD3, p53, SMA, D2-40, HMB45 and TTF- ). Conclusions Cervical macrophage neuroendocrine carcinoma is a rare and highly malignant tumor that needs to be differentiated from poorly differentiated cervical squamous cell carcinoma, poorly differentiated adenocarcinoma, carcinoid, atypical carcinoid, small cell carcinoma and other tumors.