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目的 制备水飞蓟素固体分散体 ,加快药物的溶出 ,并进行特征考察。方法 以聚乙二醇 6 0 0 0 (PEG 6 0 0 0 )为材料 ,采用熔融法将难溶性药物水飞蓟素制成固体分散体 ,通过体外释药试验考察固体分散技术对水飞蓟素的增溶作用 ,并以X 射线粉末衍射、傅立叶变换红外光谱 (FT IR)考察水飞蓟素固体分散体的特性。结果 与原药比较 ,固体分散体中药物的释放速率明显增大 ,PEG 6 0 0 0固体分散体系能显著加快水飞蓟素的溶出。X 射线粉末衍射分析表明 ,PEG 6 0 0 0及药物在固体分散体中的晶格点阵面间距离、衍射峰位移及其相对强度等均发生了规律性变化 ,FT IR分析表明PEG 6 0 0 0与药物间无相互作用。结论 PEG6 0 0 0固体分散体系的对难溶性药物溶出和扩散的加快 ,与载体材料和药物的晶格参数的改变密切相关
Objective To prepare solid dispersion of silymarin to speed up the dissolution of drugs and investigate its characteristics. Methods Polyethylene glycol 6000 (PEG 6000) was used as a solid dispersion of silymarin, a poorly soluble drug, by melt method. The solubilization of silymarin by solid dispersion technique was investigated in vitro. The properties of silymarin solid dispersions were investigated by X-ray powder diffraction and Fourier transform infrared spectroscopy (FT-IR). Results Compared with the original drug, the release rate of the drug in the solid dispersion increased obviously. The solid dispersion of PEG6000 could significantly accelerate the dissolution of silymarin. X-ray powder diffraction analysis showed that there was a regular change in the lattice spacing, the shift of the diffraction peak and the relative intensities between the PEG 6000 and the drug in the solid dispersion. FT IR analysis showed that PEG 60 0 0 no interaction with the drug. Conclusion PEG6000 solid dispersion system for the dissolution of poorly soluble drugs and diffusion speed up, and carrier materials and drugs is closely related to changes in the lattice parameters