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本文报道了用二巯丙磺钠治疗地方性慢性砷中毒的近期疗效观察。接受治疗的56例中,51例完成了1～3个疗程的治疗。作者对其疗效与疗程、疗效与疾病程度、疗效与病期之间的关系进行了密切的观察,发现完成三个疗程的有效率显著高于完成一个疗程者;疗效与疾病程度无关,角化轻度与重度者获相同的有效率;疗效与病期长短有关,病期超过10年者短期内见不到疗效。对二巯丙磺钠治疗中的不良反应作了详细的观察,除2例因皮肤过敏及头晕、恶心严重而中止治疗外,余均不影响继续治疗。本文对二巯丙磺钠的药理作用亦进行了讨论。
This article reports the short-term efficacy of sodium dimercaptopropane in the treatment of endemic chronic arsenic poisoning. Of the 56 patients treated, 51 completed 1 to 3 courses of treatment. The author of its efficacy and treatment, efficacy and disease severity, efficacy and duration of the relationship between the observed and found that the completion of the three courses was significantly higher than the efficiency of the completion of a course of treatment; the effect has nothing to do with the degree of disease, keratosis Mild and severe were the same efficiency; curative effect and the duration of the disease, the duration of more than 10 years who can not see the effect in the short term. Adverse reactions in the treatment of sodium dimercaptopropane sulphonate were observed in detail, except for 2 cases of skin allergies and dizziness, nausea and severe discontinuation of treatment, I did not affect the continued treatment. This article also discussed the pharmacological effects of sodium dimercaptopropanesulfonate.