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[目的]探讨MODS患者CD14+单核细胞人类白细胞DR抗原的表达及意义。[方法]选择MODS病人98例,用流式细胞仪测定MODS患者CD14+单核细胞人类白细胞DR抗原(HLA-DR)的动态变化及存活组与死亡组CD14+单核细胞HLA-DR含量的动态对比。[结果]所有患者首次CD14+单核细胞HLA-DR含量均﹤30%;死亡组的首次CD14+单核细胞HLA-DR含量的均小于10%,而康复组为小于30%,二者差异有统计学意义(P﹤0.01)。[结论]对MODS患者入院时应立即进行CD14+单核细胞HLA-DR动态观察,这对患者预后的判断是有价值的。
[Objective] To investigate the expression of CD14 + monocyte human leukocyte antigen (DR) in patients with MODS and its significance. [Methods] Ninety-eight MODS patients were selected. The dynamic changes of HLA-DR of CD14 + monocytes and the HLA-DR of CD14 + monocytes in survival and death groups were measured by flow cytometry . [Results] The first HLA-DR of CD14 + monocytes was less than 30% in all patients; the first group of HLA-DR of CD14 + monocytes was less than 10% in death group and less than 30% in rehabilitation group Significance (P <0.01). [Conclusion] The dynamic observation of HLA-DR of CD14 + monocytes should be performed immediately on the admission of MODS patients, which is of great value in judging the prognosis of patients.