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本文旨在研究国产18甲基炔诺酮皮下埋植剂避孕的有效性及其副反应,与Norplant作比较.666例对象经过4年观察.国产组共发生4例妊娠,4年累积妊娠率为1.07/100妇女,年平均妊娠率为0.27/100妇女,4年累积的续用率为76.6/100妇女.与国外Nor-Plant组相比较,都无统计学差异.两组副反应亦相似,主要均为月经失调,占终止者的半数以上.国产组的左旋18甲基炔诺酮的血药水平下降得较快,2年以后略低于Norplant组,但到48个月时仍在抑制排卵的血药水平.4年临床观察国产组与Norplant相似,都具有长效、高效、可逆、稳定的优点,是可供育龄妇女选用的新避孕法.
This article aims to study the domestic contraceptive effectiveness of 18 norepinephrine implants and side effects, compared with Norplant .666 cases of objects after 4 years of observation. Domestic group occurred in 4 cases of pregnancy, 4-year cumulative pregnancy rate For 1.07 / 100 women, the average annual pregnancy rate was 0.27 / 100 women, 4 years cumulative rate of 76.6 / 100 women with Nor-Plant group compared with no statistical difference between the two groups were also similar side effects , Mainly menstrual disorders, accounting for more than half of the terminator.The plasma level of L-18 norethindrone in domestic group decreased rapidly, slightly lower than Norplant group after 2 years, but still remained at 48 months 4-year clinical observation of domestic group and Norplant similar, with long-lasting, efficient, reversible, stable advantages, is the new contraception for women of childbearing age.