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目的:探讨TCT结合HPV HCⅡ检测在宫颈锥切术后患者随访中的意义。方法:将2006年1～6月经阴道镜下宫颈活检诊断为CINⅡ-Ⅲ并行宫颈锥切术、且切缘阴性的的60名患者分为4组,即TCT阴性、HPV阴性组;TCT阴性、HPV阳性组;TCT阳性、HPV阴性组;TCT阳性、HPV阳性组,对其进行2年的跟踪研究,必要时进行阴道镜检查、活检及颈管诊刮(ECC),直到观察病例出现宫颈病变或研究终止。结果:与TCT阴性、HPV阴性组,TCT阴性、HPV阳性组及TCT阳性、HPV阴性组相比,TCT阳性、HPV阳性组患宫颈癌前病变的风险度明显增高。结论:TCT结合HPV HCⅡ检测的敏感度和特异度比较理想,二者结合能满足CINⅡ-Ⅲ患者宫颈锥切术后的随访;在CIN治疗后的随访中,HPV阴性可排除复发CIN的风险。
Objective: To investigate the significance of TCT combined with HPV HC Ⅱ detection in patients following cervical conization. Methods: Sixty patients diagnosed as CINⅡ-Ⅲ concurrent cervix biopsy by colposcopic biopsy from January to June 2006 were divided into four groups (TCT negative and HPV negative). The negative TCT, HPV-positive group; TCT-positive, HPV-negative group; TCT-positive, HPV-positive group, followed up for 2 years, colposcopy, biopsy and ECC were performed when necessary, Or the study is terminated. Results: Compared with TCT-negative, HPV-negative, TCT-negative, HPV-positive, TCT-positive and HPV-negative, the risk of cervical precancerous lesions was significantly higher in TCT-positive and HPV- CONCLUSION: The sensitivity and specificity of TCT combined with HPV HCⅡ test are ideal, and the combination of the two can meet the follow-up after cervical conization in patients with CINⅡ-Ⅲ. In the follow-up after CIN treatment, HPV negative can eliminate the risk of recurrent CIN.