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Artesunate, C19H28O8, is orthorhombic and crystallizes in the space group D24 -P212121 with a = 18.781(4), b = 10.528(5), c = 9.853(5) A, Z =4, V = 1948 A3, DC = 1.310 g.cm-3, Mr = 384, F(000) = 824, m.p.= 134°-5°, dD21.5= +12.5 (c:2%, CHCl3), μ(CuKd) = 0.0867mm-1, λ(CuKd) = 1.5418A, T =293K. The X-ray study was carried out to determine the stereochemistry at the four chiral centers and to compare the skeleton of the title compound with that of Qinghaosu. The structure was solved by direct methods and refined for the 1620 reflections with I > 2σ(I) to a final R factor of 0.067.
Artesunate, C19H28O8, is orthorhombic and crystallizes in space group D24 -P212121 with a = 18.781 (4), b = 10.528 (5), c = 9.853 (5) A, Z = 4, V = 1948 A3, DC = 1.310 mp = 134 ° -5 °, dD21.5 = +12.5 (c: 2%, CHCl3), μ (CuKd) = 0.0867 mm-1, λ (CuKd) = 1.5418A, T = 293K. The X-ray study was carried out to determine the stereochemistry at the four chiral centers and to compare the skeleton of the title compound with that of Qinghaosu. The structure was solved by direct methods and refined for the 1620 reflections with I> 2σ (I) to a final R factor of 0.067.