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脂多糖刺激机体Toll样受体释放促炎细胞因子对于激活天然免疫反应发挥重要作用。在过去几年中,脂多糖/Toll样受体通路已引起人们的广泛关注与研究。但对于机体识别自身损伤的机制研究却较少。文章就Toll样受体识别内源性配体及其中的调控机制研究进展做一综述,以更好地了解Toll样受体4(Toll-like receptors 4,TLR4)在无菌性炎症中的重要作用。
Lipopolysaccharide stimulates the release of proinflammatory cytokines by Toll-like receptors in the body and plays an important role in activating the innate immune response. In the past few years, lipopolysaccharide / Toll-like receptor pathway has caused widespread concern and research. However, there are few studies on the mechanism of the body’s own damage detection. In this review, we reviewed the recent advances in the identification of endogenous ligands by Toll-like receptors and their regulatory mechanisms in order to better understand the importance of Toll-like receptors 4 (TLR4) in aseptic inflammation effect.