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目的探讨阿奇霉素对吸烟支气管哮喘患者气道炎症及生活质量的影响。方法 80例吸烟的支气管哮喘患者随机均分为治疗组与对照组。观察两组治疗12周后的肺功能变化、症状改善、生活质量改善情况及呼出气NO的水平。结果治疗组的哮喘测试评分、莱赛斯特咳嗽生命质量问卷评分、肺功能指标及呼出气NO水平在治疗12周后均较治疗前明显好转,对照组则无显著改善。除呼出气NO外,两组均显示出统计学差异,哮喘生活质量问卷调查评分较治疗前无改善,无严重不良事件。结论阿奇霉素联合吸入布地奈德福莫特罗对吸烟支气管哮喘患者的肺功能、气道炎症水平及症状有改善作用,但生活质量无明显变化,长期服用安全耐受性好。
Objective To investigate the effect of azithromycin on airway inflammation and quality of life in patients with smoking bronchial asthma. Methods Eighty patients with smoking bronchial asthma were randomly divided into treatment group and control group. The changes of pulmonary function, symptom improvement, quality of life and the level of exhaled NO were observed after 12 weeks of treatment. Results The asthma test scores, Leicester Cough Quality of Life Questionnaire score, lung function indexes and exhaled NO level in the treatment group were significantly improved after 12 weeks of treatment, while those in the control group did not significantly improve. Except exhaled NO, the two groups showed statistical differences. The asthma quality of life questionnaire did not improve before treatment and no serious adverse events were found. Conclusions Azithromycin combined inhalation of budesonide formoterol can improve pulmonary function and airway inflammation level and symptoms in patients with smoking bronchial asthma, but there is no obvious change in quality of life and safety of long-term use is good.