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据文献记载,T.B.P.反应可以作为热原检查的参考方法。四川医学院附属医院报道了关于用T.B.P.试剂应用于热原检定的初步报告,认为用T,B.P.所得的结果与临床一致。但也有的文献报道,用该试剂检查热原在灵敏度上还存在一定问题,推广普遍应用还值得考虑。为了试验该试剂是否可供检查热原之用,我们试制了T.B.P.试剂,并对临床有热原反应的注射剂进行了试验,同时用药典检查热原法作了对比,结果T.B.P.反应与药典方法所得结果不一致。为了试验该试剂和家兔对热原的灵敏度,我们试制了粗制热原,用无热原的溶媒配成不同浓度的热原溶液,用家兔及
According to the literature, T.B.P. reaction can be used as a reference method for pyrogen test. The Affiliated Hospital of Sichuan Medical College reported a preliminary report about the application of T.B.P. reagent to pyrogen test and concluded that the results obtained with T and B.P. are consistent with those of clinical trials. However, there are also some reports in the literature that pyrogen has some problems in sensitivity testing with this reagent. It is also worth considering for its widespread application. In order to test whether the reagent can be used to check the pyrogen, we made TBP reagent and tested the clinical pyrogen reaction injections. At the same time, we compared the pyrogen test with Pharmacopoeia. The results showed that TBP reaction and pharmacopoeial method The results are inconsistent. In order to test the sensitivity of the reagent and rabbit to pyrogen, we made a trial of crude pyrogen, pyrogen-free solution to pyrogen solution of different concentrations, with rabbits and