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目的:探讨用辛伐他汀治疗脑血栓的临床效果。方法:对2012年6月至2013年10月我院收治的120例脑血栓患者的临床资料进行回顾性分析,将其分为对照组和研究组,每组各60例患者。为对照组患者进行溶栓(尿激酶)治疗、调节水和电解质平衡、抗凝及抗血小板聚集等常规治疗,为研究组患者在进行常规治疗的基础上加用辛伐他汀进行治疗,并对比分析两组患者的临床疗效及发生神经功能缺损的情况。结果:与对照组患者相比,研究组患者的神经功能缺损评分较低,差异显著(P<0.05),有统计学意义。研究组患者治疗的总有效率高于对照组患者,其死亡率低于对照组患者,差异显著(P<0.05),有统计学意义。结论:为脑血栓患者应用他汀类药物辛伐他汀进行治疗的效果确切,可显著改善其神经功能,降低其死亡率,此法值得在临床上推广应用。
Objective: To investigate the clinical effect of simvastatin on cerebral thrombosis. Methods: The clinical data of 120 patients with cerebral thrombosis treated in our hospital from June 2012 to October 2013 were retrospectively analyzed. They were divided into control group and study group, 60 patients in each group. Thrombolytic therapy (urokinase) was used as the control group, routine treatment such as water and electrolyte balance, anticoagulation and anti-platelet aggregation were adjusted. Simvastatin was added to the study group on the basis of routine treatment, and compared Analysis of two groups of patients with clinical efficacy and the occurrence of neurological deficits. Results: Compared with the control group, the patients in the study group had lower neurological deficit scores (P <0.05), which was statistically significant. The total effective rate of treatment in study group was higher than that in control group, and the mortality rate of study group was lower than that of control group (P <0.05), which was statistically significant. Conclusion: The effect of statin simvastatin for patients with cerebral thrombosis is definite. It can significantly improve the neurological function and reduce the mortality rate. This method deserves to be widely used clinically.