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目的：探讨脑出血患者血浆血小板α颗粒膜蛋白（ＧＭＰ１４０）含量的变化和临床意义。方法：用放射免疫分析法测定９０例脑出血患者和７０例正常人血浆ＧＭＰ１４０的含量。结果：脑出血患者血浆ＧＭＰ１４０含量于发病１周内达高峰〔（２６．５４±７．２１）μｇ／Ｌ〕，明显高于正常对照组〔（９．０２±２．８９）μｇ／Ｌ，Ｐ＜０．０１〕，以后逐渐下降，第３周末多数降为正常〔（９．６５±３．４０）μｇ／Ｌ〕。出血量＞５０ｍｌ组血浆ＧＭＰ１４０含量〔（３９．５８±７．２９）μｇ／Ｌ〕显著高于出血量＜２０ｍｌ组〔（１５．３５±３．９０）μｇ／Ｌ，Ｐ＜０．０１〕；重型组血浆ＧＭＰ１４０含量〔（３２．１８±６．８１）μｇ／Ｌ〕明显高于轻型组〔（１３．０２±３．２１）μｇ／Ｌ，Ｐ＜０．０１〕；恶化死亡组血浆ＧＭＰ１４０含量〔（３３．３１±８．４５）μｇ／Ｌ〕明显高于治愈组〔（１４．６５±５．３４）μｇ／Ｌ，Ｐ＜０．０１〕。结论：测定脑出血患者血浆ＧＭＰ１４０含量可作为临床上估计出血量、监测病情和判断预后的一个指标。
Objective: To investigate the changes and clinical significance of plasma platelet α-granule membrane protein (GMP140) in patients with intracerebral hemorrhage. Methods: The plasma levels of GMP140 in 90 patients with cerebral hemorrhage and 70 normal individuals were determined by radioimmunoassay. Results: The peak plasma levels of GMP140 in patients with intracerebral hemorrhage reached the peak within 1 week [(26.54 ± 7.21) μg / L〕 〔(9.02 ± 2.89) μg / L, P <0.01〕, then gradually decreased, the majority of the end of the 3rd week decreased to normal 〔〕 (9.65 ± 3.40) μg / L 〔〕〕. The plasma level of GMP140 (39.58 ± 7.29 μg / L) was significantly higher than that in the group of bleeding <20 ml [(15.35 ± 3.90) μg / L, P <0.01〕 ; The level of plasma GMP140 in severe group 〔(32.18 ± 6.81) μg / L〕 was significantly higher than that in mild group 〔((13.02 ± 3.21) μg / L, P <0.01〕; The content of GMP140 [(33.31 ± 8.45) μg / L] was significantly higher than that of the cured group [(14.65 ± 5.34) μg / L, P <0.01〕. Conclusion: The determination of plasma GMP140 levels in patients with intracerebral hemorrhage can be used as an index to estimate the amount of bleeding, monitor the disease and prognosis.