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目的:探讨氨甲酰化促红细胞生成素(CEPO)对慢性心力衰竭(CHF)大鼠左心室重构的影响。方法:健康雄性Wistar大鼠90只,随机选取10只作为对照组,其余腹腔注射异丙肾上腺素(ISO)进行造模。5周后将造模成功者再分为CHF组和CEPO组,后者腹腔注射CEPO50μg/kg,2次/周,CHF组和对照组同期腹腔注射等量生理盐水,4周后检测各组大鼠血流动力学指标、血浆B型脑钠肽(BNP)水平,并计算左心室重量指数(LVW/BW)。结果:与对照组相比,CHF组左室内压峰值(LVSP)、左室内压上升/下降最大速率(±dp/dtmax)显著降低,左室舒张末压(LVEDP)显著升高(P<0.05),血浆BNP水平显著升高(P<0.05),LVW/BW也显著升高(P<0.05)。与CHF组相比,CEPO组LVSP、±dp/dtmax均显著升高,而LVEDP则显著降低(P<0.05),血浆BNP水平显著降低(P<0.01),LVW/BW也显著降低(P<0.05)。结论:CEPO可通过降低血浆BNP水平、减轻左心室重构来改善CHF大鼠的心功能。
Objective: To investigate the effect of carbamated erythropoietin (CEPO) on left ventricular remodeling in chronic heart failure (CHF) rats. Methods: Ninety healthy male Wistar rats were randomly selected as the control group. The other intraperitoneal injection of isoproterenol (ISO) was performed. After 5 weeks, the successful models were further divided into CHF group and CEPO group. The latter group received intraperitoneal injection of CEPO 50 μg / kg twice a week. The CHF group and the control group were injected intraperitoneally with the same amount of saline at 4 weeks. Hemodynamic parameters, BNP level and left ventricular mass index (LVW / BW) were calculated. Results Compared with the control group, LVSP, ± dp / dtmax and LVEDP in CHF group were significantly increased (P <0.05) ), Plasma BNP level increased significantly (P <0.05), LVW / BW also significantly increased (P <0.05). Compared with CHF group, LVSP, ± dp / dtmax and LVEDP significantly decreased (P <0.05), plasma BNP level significantly decreased (P <0.01) and LVW / BW significantly decreased in CEPO group (P < 0.05). Conclusion: CEPO can improve heart function of CHF rats by decreasing plasma BNP level and relieving left ventricular remodeling.